Oral Medicines for Validated Immunology Targets

Animated image of a dynamic protein.

A Moving Target

Proteins are dynamic, shape-shifting machines. Yet, most drug discovery tools treat them as static.

At PsiThera, we model biologically relevant protein motion to uncover hidden druggable states and design oral small molecules for disease targets long treated by injected biologics.

From Undrugged to Unlocked

Many high-value immunology targets lack chemical matter because druggable binding pockets appear minimally (or not at all) in static structures.

Our physics-native QUAISAR platform predicts when, where, and how these transient states emerge, opening new paths for oral small-molecule therapies where none previously existed.

A Pipeline of Oral Medicines for Validated Immunology Targets

PsiThera is advancing programs across multiple targets from the tumor necrosis factor (TNF) superfamily and beyond, where no oral therapies currently exist. These could become the first oral treatments in their categories. Our pipeline targets represent major opportunities to bring biologic-like efficacy to patients—without injections.

Model of CD40L Protein

sTNF𝛼

Model of OX40L Protein

mOX40L

Model of TL1A Protein

TL1A

Meet the People Making This Possible

Our team is redefining the boundaries of drug discovery by developing oral therapeutics for immunological and inflammatory disease targets traditionally addressed by biologics.

Portrait of Ana Silveira
Portrait of Jean-Christophe Harmange
Portrait of Chrissy Bracken
Portrait of Sathish Srinivasan
Portrait of Lisa Luo